3D Respiratory models

SUBTYPE:Cell Biology/Disease Modeling
DISEASE FOCUS:Respiratory/ Pulmonary
APPLICATION & SPECIALITY USES:Biomarker DiscoveryCell Therapy/ Regenerative MedicinePersonalized Medicine
Keywords:3D cell based assay3D cell cultureCell based assayOrgan Models

Our PHASEZERO scientists have extensive experience in the preparation of organotypic cultures of human bronchial epithelium, using air-liquid interface (ALI) conditions to generate highly differentiated, mucocillary cultures that mimic many of the features of the airway epithelium. The 3D-ALI model yields differentiated cultures with similar morphology to the airway epithelium. It is used to study specific epithelial function or dysfunction, including mucin secretion, goblet cell hyperplasia, barrier permeability / absorption, and development of squamous cell metaplasia. For more information regarding the ALI model, please click here to download a copy of our Mucus Hypersecretion in Respiratory Disease case study.

  • Human bronchial epithelial cells (HuBEC) prepared from high quality fresh lung
  • Cryopreserved HuBEC inventory for rapid project turnaround
  • Established assay endpoints include: Release of inflammatory mediators, mucous (goblet) cell hyperplasia, mucus secretion, squamous cell development, changes in gene expression, changes in barrier function
  • HuBECs available from donors without respiratory disease and from donors with asthma, COPD or cystic fibrosis (genotyped)

Other Relevant 3D models include:

3D Pancreatic isletORGANDOT® Model

3D Liver Fibrosis ORGANDOT® Model

3D Cancer ORGANDOT® Model