MATE2-K (SLC47A2) Transporter Assay
The MATE2-K transporter is a multi-drug and toxin extrusion transporter encoded by the SLC47A2 gene. MATE2-K is expressed in the apical membrane in the kidney and mediates the elimination of substrates.
BioIVT offers MATE2-K substrate and inhibition assays for transport in polarized mammalian cells. We offer a wide range of studies, from single concentration screens to full kinetic studies for IC50 determinations for MATE2-K inhibitors, as well as Vmax and Km studies for MATE2-K substrates.
MATE2-K Transporter Assay Details
|Relevance – Renal tubular secretion
||Single or Multi-Transporter Model – Single|
|Transporter Type – Efflux||Cell Model – MDCK-II|
|Assay Type – Intracellular accumulation||Exactly Matched Control Cells– Yes|
|Species – Human||Probe Substrate – Metformin
|Subcellular Localization in Assay Model – Apical||Inhibition Positive Control – Cimetidine