OCTN1 (SLC22A4) Transporter Assay

The OCTN1 transporter is a cation/zwitterion sodium dependent high affinity carnitine transporter. It is localized widely in many organs including the kidneys, pancreas, prostate, skeletal muscle and heart.

BiovIVT offers OCTN1 substrate and inhibition assays for transport in polarized mammalian cells. We offer a wide range of studies including single concentration screens up to full kinetic studies to determine the IC50 determinations for OCTN1 inhibitors, as well as Vmax and Km studies for OCTN1 substrates.


OCTN1 Transporter Assay Details
Relevance – Renal tubular reabsorption
Single or Multi-Transporter Model – Single
Transporter Type – Uptake Cell Model – MDCK-II
Assay Type – Intracellular accumulation Exactly Matched Control Cells– Yes
Species – Human
Probe Substrate – Ergothioneine
Subcellular Localization in Assay Model – Apical
Inhibition Positive Control – Verapamil