Alzheimer’s Disease Tissue Microarray

Type:ServicesTissue
SUBTYPE:MicroarrayProtein ExpressionCentral Nervous System
SPECIES:Diseased
DISEASE FOCUS:Neuroscience/ CNS
DISEASE SUBCATEGORIES:
FORMAT:FFPE
APPLICATION & SPECIALITY USES:Biomarker DiscoveryPersonalized Medicine
Keywords:ADAlzheimer's DiseaseAmyloidBraakDementiaMicroarrayTauTissue MicroarrayTMA

Our Alzheimer’s Disease Microarray includes samples representing three different Braak Stages (early, mid and late – 5 donors each) with associated normal controls (70 cores, with duplicate sampling for normal and quadruplicate sampling for ALZ). A representative map and key is available here. Each included AD specimen includes Braak and Amyloid scores, ApoE genotype, CSF pH, PM delay and detailed clinical histories.

The Alzheimer TMA is available as part of a services project only.

Our PHASEZERO Scientists are also able to design custom neurological TMAs to your specifications. Both FFPE and Fresh Frozen CNS arrays can be created for use in immunohistochemical or in situ hybridization studies.

BioIVT’s Tissue Microarrays (TMAs) provide our customers with a screening tool representing multiple donors. TMAs can be used to discover new protein or genetic markers and are efficient research tools for diagnostic development and validation. Tissue arrays can also be used to measure protein, RNA or DNA markers, and are compatible with immunohistochemistry (IHC) staining and potentially in situ hybridization (ISH). Standard human derived TMAs are available for research studies (from FFPE or Frozen tissue). Products are available both as sections as well as whole block. Custom TMAs are available upon request.

In addition, the following TMAs are available:

  • Lung Fibrosis Array – IPF (9), PF (4) and normal (4) lung samples, for a total of 34 x 2 cores
  • Normal Array– panel of 36 normal tissues each from 3 donors (324 x 0.6mm cores, triplicate sampling)
  • Broad Oncology  Array – 72 samples representing 12 different tumor types with associated normal controls (144 x 1.0mm cores, duplicate sampling)
  • Focused Oncology Array – 120 samples of breast, prostate, lung and colon cancer with representative normal tissue from each organ (360 x 0.6mm cores, triplicate sampling)
  • Frozen FDA Array representing 36 FDA/EMA cross-reactivity tissues arranged across three separate frozen arrays, each containing 12 non-diseased human tissues in duplicate, from three donors (72 1.5mm cores)
  • Custom designed microarrays are available through our PHASEZERO® services

Features & Benefits

  • All specimens collected using consented donors under IRB approval
  • All specimens are pre-reviewed by a board certified pathologist to confirm tissue type and diagnosis
  • High-density, high-quality with normal tissues on same TMA
  • Map and Key of each TMA available that includes clinical and donor demographics