Custom Tissue Microarrays (Frozen And FFPE Tissue, Cell Lines)

Type:Services
SUBTYPE:Gene ExpressionProtein Expression
FORMAT:FFPEFrozen
APPLICATION & SPECIALITY USES:Biomarker DiscoveryCell Therapy/ Regenerative MedicinePersonalized Medicine
Keywords:Custom TMAFDA ArraryHigh-Density TMAMicroarrayNormal TMATCRTissue MicroarrayTMATumor TMA

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BioIVT’s Tissue Microarrays (TMAs) provide our customer with a screening tool representing multiple donors. TMAs can be used to discover new protein or genetic markers and are efficient research tools for diagnostic development and validation. Tissue arrays can also be used to measure protein, RNA or DNA markers, and are compatible with immunohistochemistry (IHC) staining and potentially in situ hybridization (ISH). Standard human derived TMAs of tumor and normal samples are available for research studies (from FFPE or Frozen tissue). Products are available both as sections as well as whole block.

All specimens are collected using consented donors under IRB approval and are pre-reviewed by a board certified pathologist to confirm tissue type and diagnosis

Tissue Microarray Diseased Collection Requirements

  • All tissues isolated from consented human subjects and from IRB approved sites
  • All normal tissues are collected from human cadaver as “True Normals” or from surgical resections as adjacent normal specimens
  • Surgical donor tissue are excised within 0.5hrs, with a warm ischemic time limited to <0.5hrs, where permissible. Warm ischemic time will not exceed 1.5hrs
  • Each tissue collected is preserved with 10% NBF (neutral buffered formalin) for 18-24 hours and prepared as an FFPE tissue block
  • Each TMA is quality tested by an BioIVT registered histologist and board certified pathologist
  • Each TMA data package includes a TMA map and TMA key (patient data encompassed within output)

Tissue Microarray Normal Diagnosis Requirements

  • Diagnosis of donor tissue and disease type is confirmed by board certified pathologist
  • A donor case must be taken from unique donors
  • Normal tissue is free of tumor and can be procured from a cadaver or surgical resection
  • Normal tissue does not contain any advanced disease state, inflammation, necrosis or hemorrhage
  • Normal donor is free of systemic disease such as Parkinson’s or Huntington’s disease

Features & Benefits

  • Screen large sample set for discovery of diagnostic, prognostic or drug responsive biomarkers
  • Discover new drug targets for cancer and other diseases through exploration of molecular targets at the DNA, RNA or protein level
  • Decrease bench-time through increased high-density throughput
  • Decrease cost through improved accuracy and reproducibility with board certified pathology review of every case
  • Entire TMA block available to facilitate large or bundled analysis