2018 HEPATOPAC User Group Meeting: Driving Innovation with Long-Term HEPATOPAC® Cultures (Boston, MA)

2018 HEPATOPAC User Group Meeting
Driving Innovation with Long-Term HEPATOPAC® Cultures
Thursday, October 18, 2018
8:30 am to 4:30 pm

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BioIVT’s 2018 HEPATOPAC® User Group meeting will showcase the latest applications for HEPATOPAC cultures. Researchers from industry and academia will present how they have used HEPATOPAC cultures to investigate the ADME-Tox profiles of drug candidates and assess efficacy of new drugs in their lead selection programs.

Join us for these presentations and discussions on how HEPATOPAC Technology is being used to advance drug discovery and development programs.

  • Learn how your peers are using HEPATOPAC Technology
  • Discover ideas that you can use in your research
  • Uncover opportunities for collaboration
  • Network with industry colleagues

BioIVT representatives will also be available during breaks to discuss your specific questions or research needs.


Breakfast and Introductory Remarks – 8:30 am

Morning Sessions – 9:30 am – 12:00 pm 

Using HEPATOPAC® Cultures to Assess Efficacy & Tolerability of Antisense Oligonucleotides (ASOs)
Speaker: Todd Machemer, Toxicologist, IONIS Pharmaceuticals

miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in the Human HEPATOPAC® Model
Speaker: Merrie Mosedale, Ph.D., Research Assistant Professor, University of North Carolina, Chapel Hill

Evaluation of Transporter-Enzyme Interplay in Drug Disposition Using Micropatterned Co-cultured Hepatocytes (HEPATOPAC® Technology)
Speaker: Paresh P. Chothe, Ph.D., Research Scientist, Vertex Pharmaceuticals Inc. 

Afternoon Sessions – 1:00 – 4:30  pm

Integrated In Vitro Tools to Assess Transporter-Mediated Taurocholate Disposition
Speaker: Steven W. Louie, Director Transporter Sciences, BioIVT 

Simultaneous Assessments of ADME Readouts Using the HEPATOPAC® model for a Novel Hepatitis B Virus Inhibitor
Speaker: Nicole A. Kratochwil, Ph.D., Research Pharmacologist, Roche Pharmaceutical

How to Identify Cytochromes P450 that Mediate the Metabolism of Low Turnover Compounds Utilizing Human Pooled HEPATOPAC® Cultures
Speaker: Sheri Smith, Senior Scientist, Merck & Co, Inc

Click here for more details about the sessions and the speakers.


DoubleTree Suites by Hilton Boston, Cambridge
400 Soldiers Field Road
Boston, MA 02134