Flow Cytometry

Type:Services
SUBTYPE:Cell Biology/Disease ModelingGene ExpressionProtein Expression
APPLICATION & SPECIALITY USES:Biomarker DiscoveryCell Therapy/ Regenerative MedicineImmuno-oncologyPersonalized Medicine
Keywords:ApoptosisFACSFlow CytometryIntracellular ExpressionPhenotyping

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Flow cytometry is a versatile and powerful technology for drug discovery and development researchers and BioIVT offers a wide-range of flow analysis capabilities and support to help you determine the best strategy for your needs. Our cellular and molecular analysis services are designed to accelerate your immune monitoring, epitope discovery, immunophenotyping or cell isolation projects. With off-the-shelf solutions to customized complex flow analysis, we serve as a strategic resource with extensive capabilities to develop, validate and deploy assays for the unique examination of various parameters.

Clinical development requires a wide range of flow analysis capabilities, each with its own optimization and validation. In order to support your R&D efforts, our flow cytometry services strategically align with specific drug development programs across a wide-range of therapeutic areas. BioIVT analyzes a multitude of specimen types including whole blood, fresh and frozen tumor or normal tissue, and PBMCs/BMMCs from pre-clinical model systems and human clinical trials. Combined with our Custom Tissue Procurement Service, our Flow Cytometry Sample Analysis Service is able to isolate unique and rare primary cell populations and characterize these populations according to your needs.

Cell Analysis Assays

Immune cell phenotyping Immune cell function Intracellular cytokine
Intracellular protein Receptor occupancy Gene therapy
Signal transduction/cell signaling Hematologic malignancies Mitosis/DNA/Proliferation
 Apoptosis pathways Natural killer cell activity ADCC activity
Platelet activation

Flow Cytometry Analysis

Cell cycle regulation Tumor suppressor gene/protein expression
Proliferation/Cell cycle Translational control/Cell growth regulation
Apoptotic checkpoints Antigen-specific cell responses
Cell enumeration

 

Representative Markers

Oncology Markers Immunophenotyping Inflammation Markers Arthritis Markers
AFP CEA CD3 CD45RO IL-1 CD27
BCL-2 EpCAM CD4 CD62L IL-2 CD34
CA-125 EGFR CD8 CD66b IL-4 CD271
CA-15-3 FMC-7 CD11b CD69 IL-6 CXCR3
CD1a Hedgehog CD11c CD127 IL-10 CXCCR5
CD9 Notch CD14 CD203c IL-12 IgD
CD23 PSA CD19 FOXP3 IFN-γ
CD34 Tdt CD25 HLA-DR TNF
CD58 Wnt CD45RA NKp45
Zap-70

Features & Benefits

  • Understand mechanism of action of compounds
  • Understand response of cells to external stimul
  • Develop biomarkers for companion diagnostic development
  • Identifiy patient stratification patterns leading to improved response rates
  • Custom cell isolation and cellular characterization