XPRESSWAY Profiles – Human Ion Channel – General Family

Type:Services
SUBTYPE:Gene Expression
SPECIES:
DISEASE FOCUS:Normal Control Samples
DISEASE SUBCATEGORIES:
APPLICATION & SPECIALITY USES:Biomarker DiscoveryCell Therapy/ Regenerative MedicinePersonalized Medicine

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PHASEZERO’s XPRESSWAY® gene expression profiles are quantitative gene transcripts expression patterns across 72 tissues (3 individual donors of each) representing the major organ systems of the human body, providing a reproducible and reliable rigid assay that is essential for target validation, safety profiling and validation of animal models.
Using a rigorously controlled process, from tissue to data, PHASEZERO scientists have used the same highly sensitive, robust quantitative real-time PCR (qRT-PCR) methodology for the last 20 years ensuring reproducibility and reliability. To ensure reliability and repeatability across assays, we utilize a global standard curve inclusive of 81 genes, 150 individual standard curves and 1476 data points.

Ion Channel – General Family

The Ion Channel – General Family of XPRESSWAY PROFILES contains genes for proteins that are pore-forming membrane proteins, which allow ions to pass through the channel pore. Proteins in this family are involved in establishing a resting membrane potential, shaping action potentials as well as other electrical signals by gating the flow of ions across the cell membrane, controlling flow of ions across secretory and epithelial cells and regulating cell volume. Ion Channel Family members are present in the membranes of all cells.

Ion Channels are classified by gating, either voltage-gated, voltage gradient or ligand-gated.

Voltage-gated

  • Voltage-gated sodium channels – Nav1.1, Nav1.2, Nav1.3, Nav1.4, Navβ1
  • Voltage-gated calcium channels – Cav1.1, Cav2.1, Cav2.3
  • Voltage-gated potassium channels – kvα1.x, kvα3.x, kvα12.x
  • Transient receptor potential channels TRPC, TRPV, TRPA, TRPM, TRPP, TRPML
  • Cyclic nucleotide-gated channels- CNGA1, CNGA2, CNGA3, CNGB1
  • Voltage-gated proton channels – HVCN1
Ligand-gated
  • Cys-loop Receptors
    • Cationic cys-loop receptors – 5HT3, nACh4R, ZAC
    • Anionic cys-loop receptors – GABAA, GlyR
  • Ionotropic Glutamate Receptors – AMPA, KAinate, NMDA
  • AMPA Receptor
  • NMDA Receptors

Profiles are purchased with a license and you will be provided in a full profile report. While any number of profiles may be purchased, if you are purchasing more than 20 profiles, please contact customer service so that we may contact you for special tiered pricing.

Over 2300 existing profiles are immediately available and new profiles rapidly generated on request.

XPRESSWAY Sample Reports

BioIVT_XPRESSWAY_Sample-Report

Data are provided in the format of PDF reports containing the relevant information regarding the target gene, data and donor details. The raw data for the target gene and GAPDH, together with the donor details, are also provided in Excel format to enable the data to be presented in any format required by the client.

XPRESSWAY profile reports contain:

  • Gene expression data, including Stellar plot, SwissProt™ name and description
  • Nucleotide accession number
  • Sequence of Forward primer, Reverse primer and Probe
  • Gene expression data for GAPDH
  • Gene expression data for tissue not selected (anonymized)
  • Correlation report

Features & Benefits

XPRESSWAY Platform Design for Human Tissues

  • 72 tissues each from 3 different donors
  • Pathologically normal tissues
  • Tissues procured with informed consent and appropriate ethical approval for research use
  • All donor information and tissue pathology are provided