We design and implement evaluations of hepatotoxicity including the following assessment programs:
- Cholestatic Hepatotoxicity
Clients use the reports from our cytotoxicity studies in their lead selection and optimization studies, and for determining the dose range in other in vitro programs.
We recommend using TRANSPORTER CERTIFIED™ hepatocytes in sandwich culture for hepatotoxicity studies. Our methodology ensures that hepatic uptake and efflux transporters are functioning in the model, and therefore intracellular concentrations (ICC) reflect physiologic conditions in vivo.