Human Cryoplateable Hepatocytes

Type:Cell Products
SUBTYPE:Hepatocytes
SPECIES:Normal
FORMAT:Cryopreserved
APPLICATION & SPECIALITY USES:ADME-Toxicology Products and Services
Keywords:HepatalertHepatocytesHumanInductionMetabolismPlateableToxicology

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Hepatocytes from BioIVT are cryopreserved the same day they are isolated, and come with full serology reporting for your safety. Cryoplateable human hepatocytes are used for long term studies (≥4 hours) like induction, toxicity, and transport. More recently, scientists also have been using cryoplateable hepatocytes to study transporter efflux, viral transduction and gene induction.

BioIVT cryoplateable human hepatocytes have high levels of induction following treatment with known inducers omeprazole (CYP1A2), phenobarbital (CYP2B6), and rifampin (CYP3A4). All plateable lots have greater than 70% viability and greater than 70% confluence on day 5. Cells are also treated with CDFDA fluorescent dye to show bile caniculi formation

  • Convenience. No waiting for fresh livers
  • High Quality. Established responsiveness to inducers
  • Full Characterization. Known phenotypes and donor demographics
  • Reproducibility. Allows multiple experiments at different times from a single donor
  • Easy to Use. Allows multiple donor studies in the same experiment
  • Quick Response. HepatA!ert™ notifies customers when new lots of cryoplateable human hepatocytes are available
  • High Throughput. Use in 96-, 384- and 1536-well plates.

Caution: Treat all products containing human materials as potentially infectious, as no known test methods can offer assurance that products derived from human tissues will not transmit infectious agents.

All products are for research use only. Do not use in animals or humans. These products have not been approved for any diagnostic or clinical procedures.

Cryosuspensions are >80% viable and contain a minimum of 5 million cells per vial as determined by Trypan Blue exlcusion.

Cryoplateable hepatocytes have a :  ≥70% confluent monolayer on day 5

BioIVT provides’ technical support to our customers and this support includes onsite demos or training for handling our hepatocyte, microsome and S9. We have a group of Scientific Advisors that regularly visit customers to discuss their research and ongoing studies. If there are any questions or concerns about the use of our products or a protocol contact our Scientific Advisors for additional help.