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The ACCULIVER™ CYP450 Induction Kit is used to assess the CYP450 induction potential of a test article. The kit includes materials which enable establishment of a model, that, when combined with TRANSPORTER CERTIFIED™ hepatocytes, has demonstrated better in vitro-in vivo correlation than conventional, transporter-deficient models. TRANSPORTER CERTIFIED hepatocytes, when cultured in the conditions described in the manual, express physiologically-relevant transporter function resulting in in vivo-relevant intracellular concentrations making the model more appropriate to predict induction potential..
The ACCCULIVER CYP450 Induction Kit contains the following items needed for the indcution assay: