Microsomes are valuable tools in drug discovery for studying the metabolism of your compounds. Microsomes are artificial, vesicle-like structures formed from pieces of the endoplasmic reticulum during the tissue homogenization step. BioIVT manufactures microsomes through a differential centrifugation process at varying speeds resulting in purified microsomal product.
Microsomes contain a family of cytochrome P450 enzymes (CYPs) which are responsible for phase I metabolism of xenobiotics. Microsomes also contain other membrane proteins like UGT and FMO.
BioIVT manufactures a wide variety of options when it comes to microsomes. Our standard product offering includes microsomes prepared from fresh human and animal liver tissue. However, custom preparations using other tissue types like brain, kidney, lung, intestine, heart and skin are requested often.
Microsomes can be customized to your specifications: