TRANSFLEX™ Assay-Ready Transporter Plates

Type:Cell Products
SUBTYPE:Transporter Products
SPECIES:
APPLICATION & SPECIALITY USES:ADME-Toxicology Products and Services
Keywords:IND-enablingTransporters

TRANSFLEX Plates provide researchers with a convenient way to conduct transporter assays in their own laboratories. From studies evaluating one compound in a variety of transporters to numerous compounds in one transporter, plates are customized to meet research requirements and are available in the following formats:

  • Single-Transporter Assays: Cells expressing one transporter
  • Multi-Transporter Models: Cells expressing more than one transporter

TRANSFLEX Plates are produced using OPTI-EXPRESSION Technology and consist of MDCK-II cells that express various combinations of uptake and / or efflux transporters. Plates may be configured for a broad assortment of experimental designs, and offer the following benefits:

  • Rapid custom synthesis and shipment
  • Ready-to-use 24 hours after receipt
  • Suitable for substrate and inhibition studies
  • 96-well format
  • Flexible plate configurations that allow multiple transporter options plus control cells on the same plate
  • No cell line development or maintenance

Flexible Transporter Assay Configurations

As illustrated in this diagram TRANSFLEX Plates can be designed based on study requirements. We routinely provide the following single-transporter assay, and multi-transporter model plates to our clients.

 

Single-Transporter Assay Plates
BCRP
DAT
EAAT1
EAAT2
GAT1
GAT2
GAT3
MATE1
MATE2-K
MDR1/P-gp
NET
NTCP
OATP1B1
OATP1B3
OAT1
OAT4
OCT1
OCT2
P-gp/MDR1
SERT
xCT
Multi-Transporter Model Plates
OCT2 + MATE1
OCT2 + MATE2-K
OATP1B1 + BCRP
OATP1B1 + MRP2
OATP1B3 + BCRP
NTCP + BSEP
OCT2 + MATE1 + MATE2-K
OATP1B1 + NTCP + BSEP