Assess Uptake DDI Risk

SUBTYPE:Hepatobiliary Disposition
APPLICATION & SPECIALITY USES:ADME-Toxicology Products and Services
Keywords:Hepatic ClearanceHepatic UptakeOil SpinPlated HepatocytesSuspension Hepatocytes

If the uptake assessment study indicates that active uptake occurs, we recommend assessing uptake DDIs. Our study design uses standard, well-described probe substrates and evaluates the potential of the test article to inhibit their uptake, and thus predict the potential for DDIs.

Uptake DDI studies may be implemented using suspension or plated hepatocytes.